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Among them, the wet mixing granulator is a pharmaceutical preparation for solid preparations that has developed rapidly in recent years. The two-step mixing and granulation process is combined in the process, which saves time and satisfies GMP requirements and reduces crossover. At the same time as pollution, the efficiency of granulation has been improved. It is a quick and easy way to save the food. It is welcomed by users and widely used in pharmaceutical, food, chemical and other industries.
In the pharmaceutical industry, according to relevant statistics, wet mixing granulators account for 70% of the current market for several solid preparation granulation equipment. Due to the use of the wet mixing granulator and the tablet press, the sales volume of the wet mixing granulator has a high market share throughout the year.
The pharmaceutical industry is steadily moving forward, and the requirements for the wet process are getting higher and higher. The wet granulation technology naturally needs to advance with the times. Only a more efficient, environmentally friendly and safe granulation method can be used in the market. The current market is unpredictable. Wet-mixing granulators must seize market development trends. While maintaining their own advantages in price and ease of maintenance, they should continue to improve their deficiencies and improve their technological capabilities so that they can be better used in pharmaceuticals. field.
It is understood that, in foreign countries, wet mixing granulators have been widely adopted and started late in China. The industry stated that some domestic users chose pharmaceutical equipment from non-professional manufacturers. When they were commissioned on site, they did not understand the preparation process and did not understand the use of skills. The results often failed and they suffered. For the development of solid preparations in China, to help users make good use of the purchased wet mixing equipment, people in the industry have published some knowledge for your reference. The author made the following arrangements.
In general, the particles produced by the wet-mixing granulation have irregular shapes and uniform particle size distribution. The structure is more perfect than other conventional granulation processes, and has strong compressibility, good solubility, and moderate moisture permeability. At different granulation speeds, the particle size of the particles is between 12 and 100 meshes. The distribution range can be obtained by selecting the rotation speed of the pelletizing paddle and the rotation speed of the stirring paddle (when the pelletizing paddle rotates at a slow speed, the particle size becomes larger and the rotation speed gradually increases. Accelerated and gradually smaller particle size; when the rotating speed of the stirring blade is small, the particle size is small, and the rotation speed gradually becomes faster and the particle size gradually increases. The two functions are just opposite.
The conventional wet mixing granulator can manually adjust the rotational speed of the stirring paddle and the pelletizing paddle in order to find out experimental process parameters. That is to say, the speed of the two kinds of blades is changed through different time, and the better particle size parameters are obtained. According to this, two frequency converters are input to perform program control, thereby ensuring the quality of the batch and batch production to be stable and uniform.
Wet mixing granulator tips
In recent years, China's pharmaceutical industry has developed rapidly. Research and development of related equipment has also been highly valued by the pharmaceutical equipment industry. The current theme of environmental protection has been mentioned before, and the granulation equipment manufacturers must grasp the transformation and upgrading of equipment and the improvement of the wet process in order not to be eliminated by the market.